Npr3^{tm2(cre/ERT2)Hze}
Targeted Allele Detail

Summary

• Symbol: Npr3^{tm2(cre/ERT2)Hze}
• Name: natriuretic peptide receptor 3; targeted mutation 2, Hongkui Zeng
• MGI ID: MGI:7571411
• Synonyms: Npr3-IRES2-CreERT2-neo
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^{tm2(cre/ERT2)Hze} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Mutation: Insertion
• Npr3^{tm2(cre/ERT2)Hze} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npr3 (MGI:97373)

• Mutation details: The targeting vector contains, from 5' to 3', a partial Npr3 sequence spanning intron 6 up to and including the endogenous stop codon in exon 8 (also with a frt3 site in intron 7), an internal ribosome entry site 2 sequence (IRES2; allows translation initiation in the middle of an mRNA sequence), a cre/ERT2 gene, a bovine growth hormone polyA sequence, an AttB site, a PGK/gb2 promoter-Neomycin resistance gene-PGK polyA cassette, a frt5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 polyA signal, and an AttP site. (J:101977)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npr3 (mouse) Summary of all recombinase alleles driven by Npr3. Alliance mouse Npr3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 50 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)