Rtl9^em2Tmki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rtl9^em2Tmki
• Name: retrotransposon Gag like 9; endonuclease-mediated mutation 2, Tomoko Kaneko-Ishino
• MGI ID: MGI:7571418
• Synonyms: Rtl9deltaC
• Gene: Rtl9 Location: ChrX:141876886-141887293 bp, + strand Genetic Position: ChrX, 64.02 cM
• Alliance: Rtl9^em2Tmki page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology using crRNAs 5-TCATAGCTGCAAATTGTGCA-3 and 5-AGAAATCACATAAGATTCCA-3 inserted a 3x stop codon in the C-terminal region generating a protein lacking the C-terminus retroviral GAG-like region. (J:343808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtl9 Mutation: 7 strains or lines available

References

• Original: J:343808 Ishino F, et al., Retrovirus-Derived RTL9 Plays an Important Role in Innate Antifungal Immunity in the Eutherian Brain. Int J Mol Sci. 2023 Oct 4;24(19)
• All: 1 reference(s)