Tg(Prnp-APPSwe,-PSEN1*)48Gpt
Transgene Detail

Summary

• Symbol: Tg(Prnp-APPSwe,-PSEN1*)48Gpt
• Name: transgene insertion 48, GemPharmatech Co Ltd
• MGI ID: MGI:7572418
• Synonyms: Tg(APP,hPSEN1)48
• Transgene: Tg(Prnp-APPSwe,-PSEN1*)48Gpt Location: unknown
• Alliance: Tg(Prnp-APPSwe,-PSEN1*)48Gpt page

Transgene origin

• Strain of Origin: C57BL/6JGpt

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-APPSwe,-PSEN1*)48Gpt expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Tg(Prnp-APPSwe,-PSEN1*)48Gpt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: Two transgenes inserted at a single locus in Chromosome 9 between Arpp21 and Pdcd6ip. Each transgene is controlled by the mouse prion promoter and contains a cDNA sequence. In one transgene the cDNA encodes a chimeric amyloid beta (A4) precursor protein (APPswe). In the second transgene the cDNA encodes the "DeltaE9" mutation of human presenilin 1. The DeltaE9 mutation of the human presenilin 1 gene is a deletion of exon 9 and corresponds to a form of early-onset Alzheimer's disease. The amyloid beta precursor protein coding sequences were altered by replacing mouse sequence encoding three amino acids of the A-beta domain with the human coding sequence for these residues. (J:293217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)