Cyp4v3^em1Xsu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp4v3^em1Xsu
• Name: cytochrome P450, family 4, subfamily v, polypeptide 3; endonuclease-mediated mutation 1, Xiaodong Sun
• MGI ID: MGI:7574754
• Gene: Cyp4v3 Location: Chr8:45758838-45786200 bp, - strand Genetic Position: Chr8, 25.17 cM
• Alliance: Cyp4v3^em1Xsu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 430-bp deletion of exon 1. RT-qPCR confirmed the absence of mRNA in the retina and retinal pigment epithelium-choroid complex. (J:321817)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp4v3 Mutation: 36 strains or lines available

References

• Original: J:321817 Wang Y, et al., A novel and efficient murine model of Bietti crystalline dystrophy. Dis Model Mech. 2022 Mar 1;15(3):dmm049222
• All: 1 reference(s)