Ccdc146^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc146^em1Cya
• Name: coiled-coil domain containing 146; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7577422
• Gene: Ccdc146 Location: Chr5:21497959-21629675 bp, - strand Genetic Position: Chr5, 9.83 cM, cytoband A3
• Alliance: Ccdc146^em1Cya page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 3 to 7. Western blot analysis confirmed the absence of protein in testis. (J:344445)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccdc146 Mutation: 53 strains or lines available

References

• Original: J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1
• All: 1 reference(s)