Apol6^em1Hsul
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apol6^em1Hsul
• Name: apolipoprotein L 6; endonuclease-mediated mutation 1, Hei Sul
• MGI ID: MGI:7578884
• Synonyms: ApoL6 KO
• Gene: Apol6 Location: Chr15:76929195-76941308 bp, + strand Genetic Position: Chr15, 36.39 cM, cytoband E1
• Alliance: Apol6^em1Hsul page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an 11 bp deletion in the coding region of the third exon, 18 bp after the translation start site. Immunoblotting confirmed the absence of protein expression in white and brown adipose tissue of homozygous mutant mice, with no detectable compensation from other ApoL family members. (J:344362)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apol6 Mutation: 19 strains or lines available

References

• Original: J:344362 Wang Y, et al., ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. Nat Commun. 2024 Jan 2;15(1):186
• All: 1 reference(s)