Tg(Adipoq-Apol6)#Hsul
Transgene Detail

Summary

• Symbol: Tg(Adipoq-Apol6)#Hsul
• Name: transgene insertion, Hei Sul
• MGI ID: MGI:7578892
• Synonyms: adipoQ-ApoL6 TG
• Transgene: Tg(Adipoq-Apol6)#Hsul Location: unknown
• Alliance: Tg(Adipoq-Apol6)#Hsul page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Adipoq-Apol6)#Hsul expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Apol6 (MGI:1919189)

• Tg(Adipoq-Apol6)#Hsul expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Adipoq (MGI:106675)

• Mutation details: Expression of a Apol6 gene with a HA tag is driven by a -5.2kb adiponectin promoter. No line numbers nor species of components were provided. Immunoblotting showed that APOL6 protein levels are 3- to 4-fold higher than those in wild-type mice. (J:344362)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:344362 Wang Y, et al., ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. Nat Commun. 2024 Jan 2;15(1):186
• All: 1 reference(s)