Tg(Fabp4-Apol6)#Hsul
Transgene Detail

Summary

• Symbol: Tg(Fabp4-Apol6)#Hsul
• Name: transgene insertion, Hei Sul
• MGI ID: MGI:7578893
• Synonyms: aP2-ApoL6 TG
• Transgene: Tg(Fabp4-Apol6)#Hsul Location: unknown
• Alliance: Tg(Fabp4-Apol6)#Hsul page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-Apol6)#Hsul expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Apol6 (MGI:1919189)

• Tg(Fabp4-Apol6)#Hsul expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fabp4 (MGI:88038)

• Mutation details: Expression of a Apol6 gene with a Myc tag is driven by a 5.4 kb aP2 (FABP4) promoter. No line numbers nor species of components were provided. This transgene is expressed specifically in white and brown adipose tissue and is barely detectable in other tissues. Immunoblotting showed that APOL6 protein levels are ~3-fold higher than those in wild-type mice. (J:344362)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:344362 Wang Y, et al., ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. Nat Commun. 2024 Jan 2;15(1):186
• All: 1 reference(s)