Ts(17¹⁶;EIF1AX-Xist)67Jlaw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ts(17¹⁶;EIF1AX-Xist)67Jlaw
• Name: trisomy, Chr 16 translocation to Chr 17, Jeanne Lawrence 67
• MGI ID: MGI:7579215
• Synonyms: Igs50^{em1(EIF1AX-Xist)Jlaw}, Ts65DN-Xist
• Gene: Ts(17¹⁶;EIF1AX-Xist)67Jlaw Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: B6EiC3Sn a/A-Ts(17¹⁶)65Dn/J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutations: Insertion, Translocation
• Ts(17¹⁶;EIF1AX-Xist)67Jlaw expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Xist (MGI:98974)

• Ts(17¹⁶;EIF1AX-Xist)67Jlaw expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  EIF1AX (1964)

  Eif1a	(MGI:95298)
  Eif1ax	(MGI:1913485)

• Mutation details: Using CRISPR/Cas9 technology, the mouse Xist gene, driven by human eukaryotic translation initiation factor 1A X-linked (EIF1AX) promoter was inserted downstream of the Runx1 locus on chromosome 16 (a low-gene density region designated as Igs50) of the trisomy chromosome 16 in the host ES cell derived from B6EiC3Sn a/A-Ts(17<16>)65Dn/J line. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ts(17 16 ;EIF1AX-Xist)67Jlaw Mutation: 0 strains or lines available

Notes

ES cell derived from B6EiC3Sn a/A-Ts(17<16>)65Dn/J line.

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)