Atp9a^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atp9a^em1Bcgen
• Name: ATPase, class II, type 9A; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7580494
• Gene: Atp9a Location: Chr2:168476358-168584290 bp, - strand Genetic Position: Chr2, 88.99 cM, cytoband H3
• Alliance: Atp9a^em1Bcgen page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 223-bp deletion that deleted exons 3-4 and resulted in an open reading frame shift. (J:335674)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp9a Mutation: 79 strains or lines available

References

• Original: J:335674 Meng T, et al., ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity. Mol Psychiatry. 2023 Mar;28(3):1219-1231
• All: 1 reference(s)