Srsf4^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Srsf4^{tm1c(EUCOMM)Wtsi}
• Name: serine and arginine-rich splicing factor 4; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7580838
• Synonyms: SRSF4 floxed
• Gene: Srsf4 Location: Chr4:131600928-131629017 bp, + strand Genetic Position: Chr4, 64.53 cM
• Alliance: Srsf4^{tm1c(EUCOMM)Wtsi} page
• IMPC: Srsf4 gene page

Mutation origin

• Mutant Cell Line: EPD0039_1_C07
• Germline Transmission: Earliest citation of germline transmission: J:344969
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt2
• Mutation details: The L1L2_gt2 cassette was inserted at position 131618285 of Chromosome 4 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 131618884. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:344969)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf4 Mutation: 46 strains or lines available

References

• Original: J:344969 Larrasa-Alonso J, et al., The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy. Circ Res. 2021 Sep 3;129(6):669-683
• All: 1 reference(s)