Espnl^em1Pgg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Espnl^em1Pgg
• Name: espin-like; endonuclease-mediated mutation 1, Peter G Gillespie
• MGI ID: MGI:7581062
• Synonyms: Espnl^delta
• Gene: Espnl Location: Chr1:91249797-91276028 bp, + strand Genetic Position: Chr1, 46.08 cM
• Alliance: Espnl^em1Pgg page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion spanning from exon 1 to exon 8. This allele (c.135_1301del1165) forms protein p.A46Tfs14 and is referred to as Espnl^delta. No labeling with BG35961 anti-ESPNL antibody was detected in cochlear hair bundles of homozygous mutant mice, indicating that this is a null allele. (J:236347)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Espnl Mutation: 30 strains or lines available

References

• Original: J:236347 Ebrahim S, et al., Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Nat Commun. 2016 Mar 01;7:10833
• All: 1 reference(s)