Espnl^em2Pgg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Espnl^em2Pgg
• Name: espin-like; endonuclease-mediated mutation 2, Peter G Gillespie
• MGI ID: MGI:7581066
• Synonyms: Espnl^A
• Gene: Espnl Location: Chr1:91249797-91276028 bp, + strand Genetic Position: Chr1, 46.08 cM
• Alliance: Espnl^em2Pgg page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate c.1298_1299insA, which has a single adenine (A) inserted in exon 8. This allele is predicted to form a truncated protein (p.Q433Qfs10) and is referred to as Espnl^A. No immunoreactivity was detected in mice homozygous for this mutation using the BG35961 anti-ESPNL antibody. (J:236347)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Espnl Mutation: 30 strains or lines available

References

• Original: J:236347 Ebrahim S, et al., Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Nat Commun. 2016 Mar 01;7:10833
• All: 1 reference(s)