Del(14Gjb6-Cryl1)1Lmon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(14Gjb6-Cryl1)1Lmon
• Name: deletion, Chr 14, Lluis Montoliu
• MGI ID: MGI:7581999
• Synonyms: Dfnb1(em274)
• Gene: Del(14Gjb6-Cryl1)1Lmon Location: unknown Genetic Position: Chr14, Syntenic

Mutation origin

• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(14Gjb6-Cryl1)1Lmon involves 8 genes/genome features (Gjb6, Gm48725, Gm8996 ...) View all
• Mutation details: Deletion that spans 274,050 bp of mouse chromosome 14, from Gjb6 exon3 to Cryl1 exon 1, engineered by CRISPR-Cas9. (J:345081)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(14Gjb6-Cryl1)1Lmon Mutation: 0 strains or lines available

Notes

The expression of the Gjb2 gene, located proximally to the deletion, is nearly abolished in all cochlear structures.

References

• Original: J:345081 Dominguez-Ruiz M, et al., A Murine Model for the del(GJB6-D13S1830) Deletion Recapitulating the Phenotype of Human DFNB1 Hearing Impairment: Generation and Functional and Histopathological Study. 2024
• All: 1 reference(s)