Hspb6^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hspb6^em1Cya
• Name: heat shock protein, alpha-crystallin-related, B6; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7584374
• Synonyms: Hspb6^em1, HSPB6^KO
• Gene: Hspb6 Location: Chr7:30251961-30254868 bp, + strand Genetic Position: Chr7, 18.56 cM
• Alliance: Hspb6^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 and exon 3 were selected as target sites. Western blot analysis demonstrated a significant reduction of HSPB6 and phosphorylated HSPB6 (P-HSPB6) protein levels in the aortic tissues of homozygous mutant mice. (J:326541)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hspb6 Mutation: 11 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 2 reference(s)