Socs4^m1Nch
Chemically induced Allele Detail

Summary

• Symbol: Socs4^m1Nch
• Name: suppressor of cytokine signaling 4; mutation 1, Sandra E Nicholson
• MGI ID: MGI:7587716
• Synonyms: Socs4^R108X
• Gene: Socs4 Location: Chr14:47514388-47533559 bp, + strand Genetic Position: Chr14, 24.6 cM
• Alliance: Socs4^m1Nch page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C-to-T change in arginine codon 108 (CGA), changing it to a stop codon (TGA) (p.R108*). (J:241977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs4 Mutation: 21 strains or lines available

References

• Original: J:241977 Kedzierski L, et al., Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathog. 2014 May;10(5):e1004134
• All: 3 reference(s)