Lrrn1^em2Dri
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrn1^em2Dri
• Name: leucine rich repeat protein 1, neuronal; endonuclease-mediated mutation 2, Elizabeth Carroll Driver
• MGI ID: MGI:7593846
• Gene: Lrrn1 Location: Chr6:107506729-107547175 bp, + strand Genetic Position: Chr6, 49.71 cM
• Alliance: Lrrn1^em2Dri page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated recombination created a 4 bp deletion in the 10th leucine-rich repeat in the extracellular domain of the gene. Immunolabelling assays confirmed the absence of full length protein in the cochlea from homozygous embryos. (J:344891)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrn1 Mutation: 44 strains or lines available

References

• Original: J:344891 Maunsell HR, et al., Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci. 2023 Jul 19;43(29):5305-5318
• All: 1 reference(s)