Fscn3^em1Qsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fscn3^em1Qsh
• Name: fascin actin-bundling protein 3; endonuclease-mediated mutation 1, Qinghua Shi
• MGI ID: MGI:7594032
• Gene: Fscn3 Location: Chr6:28427888-28438621 bp, + strand Genetic Position: Chr6, 11.99 cM, cytoband A3
• Alliance: Fscn3^em1Qsh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of two base pairs in exon 4 (c.1062-1063del, frameshift mutation), which is expected to cause premature termination of translation (p.Asn354Lysfs9*). (J:345144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fscn3 Mutation: 24 strains or lines available

References

• Original: J:345144 Ali H, et al., Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility. Mol Biol Rep. 2022 Jul;49(7):6261-6268
• All: 1 reference(s)