Sdhaf4^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sdhaf4^em1Bcgen
• Name: succinate dehydrogenase complex assembly factor 4; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7596072
• Synonyms: Sdhaf4^fl
• Gene: Sdhaf4 Location: Chr1:24035020-24044721 bp, - strand Genetic Position: Chr1, 9.86 cM
• Alliance: Sdhaf4^em1Bcgen page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/cas9-mediated recombination inserted loxP sites flanking a ~3kb region including exons 1 and 2. (J:345348)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sdhaf4 Mutation: 6 strains or lines available

References

• Original: J:345348 Wang X, et al., Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nat Commun. 2022 Jul 8;13(1):3947
• All: 1 reference(s)