Sptbn5^tm1.1Dsna
Targeted Allele Detail

Summary

• Symbol: Sptbn5^tm1.1Dsna
• Name: spectrin beta, non-erythrocytic 5; targeted mutation 1.1, Dhasakumar S Navaratnam
• MGI ID: MGI:7596140
• Synonyms: Spnb5^-
• Gene: Sptbn5 Location: Chr2:119871974-119916159 bp, - strand Genetic Position: Chr2, 60.11 cM
• Alliance: Sptbn5^tm1.1Dsna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345361
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 2. Cre-mediated recombination removed both the selection cassette and exon 2. (J:345361)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptbn5 Mutation: 59 strains or lines available

References

• Original: J:345361 Stankewich MC, et al., Outer hair cell function is normal in betaV spectrin knockout mice. Hear Res. 2022 Sep 15;423:108564
• All: 1 reference(s)