Zfp746^em1Jhsn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp746^em1Jhsn
• Name: zinc finger protein 746; endonuclease-mediated mutation 1, Joo-Ho Shin
• MGI ID: MGI:7607238
• Synonyms: Paris KO
• Gene: Zfp746 Location: Chr6:48039329-48063527 bp, - strand Genetic Position: Chr6, 23.04 cM
• Alliance: Zfp746^em1Jhsn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an 11 bp deletion (AGGCTATGGAG) in exon 2. Immunoblot analysis confirmed absence of protein in the liver of homozygotes. (J:344819)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp746 Mutation: 22 strains or lines available

References

• Original: J:344819 Kim H, et al., ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma. Biochem Biophys Res Commun. 2021 Jul 23;563:98-104
• All: 1 reference(s)