Tg(Thy1-MAPT*P301S)58.2Npa
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*P301S)58.2Npa
• Name: transgene insertion 58.2, Novartis Pharma AG
• MGI ID: MGI:7608047
• Synonyms: Tau58/2
• Transgene: Tg(Thy1-MAPT*P301S)58.2Npa Location: unknown
• Alliance: Tg(Thy1-MAPT*P301S)58.2Npa page

Transgene origin

• Strain of Origin: C57BL/6 x BALB/c

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*P301S)58.2Npa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  Tau isoform 0N4R containing P301S mutation

• Tg(Thy1-MAPT*P301S)58.2Npa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Thy1 (MGI:98747)

• Mutation details: This transgene expresses the human 0N4R tau isoform with the P301S mutation under the control of the mouse Thy1.2 neuron specific promoter. (J:303695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:303695 van Eersel J, et al., Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration. Neuropathol Appl Neurobiol. 2015 Dec;41(7):906-25
• All: 6 reference(s)