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Trim29tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Trim29tm1c(EUCOMM)Wtsi
Name: tripartite motif-containing 29; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:7608151
Synonyms: trim29fl, Trim29fl
Gene: Trim29  Location: Chr9:43222145-43247412 bp, + strand  Genetic Position: Chr9, 24.28 cM
Alliance: Trim29tm1c(EUCOMM)Wtsi page
IMPC: Trim29 gene page
Mutation
origin
Mutant Cell Line:  EPD0439_4_D01
Germline Transmission:  Earliest citation of germline transmission: J:345541
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 43230340 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 43233918. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:345541)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim29 Mutation:  28 strains or lines available
References
Original:  J:345541 Dou Y, et al., Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions. J Immunol. 2019 Aug 15;203(4):873-880
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory