Trim29tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Trim29tm1c(EUCOMM)Wtsi |
Name: |
tripartite motif-containing 29; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7608151 |
Synonyms: |
trim29fl, Trim29fl |
Gene: |
Trim29 Location: Chr9:43222145-43247412 bp, + strand Genetic Position: Chr9, 24.28 cM
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Alliance: |
Trim29tm1c(EUCOMM)Wtsi page
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IMPC: |
Trim29 gene page |
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Mutant Cell Line: |
EPD0439_4_D01 |
Germline Transmission: |
Earliest citation of germline transmission:
J:345541
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 43230340 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 43233918. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:345541)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trim29 Mutation: |
28 strains or lines available
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Original: |
J:345541 Dou Y, et al., Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions. J Immunol. 2019 Aug 15;203(4):873-880 |
All: |
3 reference(s) |
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