Pja2^tm1.2Afel
Targeted Allele Detail

Summary

• Symbol: Pja2^tm1.2Afel
• Name: praja ring finger ubiquitin ligase 2; targeted mutation 1.2, Antonio Feliciello
• MGI ID: MGI:7610503
• Synonyms: praja2^-
• Gene: Pja2 Location: Chr17:64588001-64638878 bp, - strand Genetic Position: Chr17, 33.24 cM
• Alliance: Pja2^tm1.2Afel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345592
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 2. The neomycin selection cassette was removed via flp-mediated recombination. Exons 1-2 were deleted via cre-mediated recombination. (J:345592)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pja2 Mutation: 47 strains or lines available

References

• Original: J:345592 Rinaldi L, et al., Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. Commun Biol. 2024 Feb 20;7(1):208
• All: 1 reference(s)