Gmppb^em1Frap
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gmppb^em1Frap
• Name: GDP-mannose pyrophosphorylase B; endonuclease-mediated mutation 1, Patricia Franzka
• MGI ID: MGI:7610557
• Gene: Gmppb Location: Chr9:107926490-107929119 bp, + strand Genetic Position: Chr9, 59.07 cM
• Alliance: Gmppb^em1Frap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345599
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using two guide RNAs targeting exon 4 created a 54 bp deletion. (J:345599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gmppb Mutation: 16 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:345599 Schurig MK, et al., Consequences of GMPPB deficiency for neuromuscular development and maintenance. Front Mol Neurosci. 2024;17:1356326
• All: 1 reference(s)