Slc24a3^em#Ebje
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc24a3^em#Ebje
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; endonuclease-mediated mutation, Eui-Bae Jeung
• MGI ID: MGI:7610675
• Synonyms: NCKX3^-
• Gene: Slc24a3 Location: Chr2:145009695-145484086 bp, + strand Genetic Position: Chr2, 71.08 cM, cytoband H1
• Alliance: Slc24a3^em#Ebje page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc-finger nucleases (ZFNs) technology targeting exon 10 generated deletion alleles ranging from 1 to 51 bp. Seven founders were bred, one of which was bred to homozygosity. The pound (#) sign is used because the line used is not specified and could be one of the following lines: z7 with 18 bp deletion, z9 with 14 bp deletion, z10 with 1 bp deletion, z15 with 11 bp deletion, z21 with 18 bp deletion, z22 with 12 bp deletion, or z26 with 51 bp deletion or the lines have been pooled. Western blot analysis confirmed absence of protein in homozygotes. (J:254307)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc24a3 Mutation: 28 strains or lines available

References

• Original: J:254307 Yang H, et al., NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model. Mol Cell Endocrinol. 2017 Oct 15;454:93-102
• All: 3 reference(s)