Hcar1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Hcar1^tm1Lex
• Name: hydrocarboxylic acid receptor 1; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:7612088
• Gene: Hcar1 Location: Chr5:124014802-124018066 bp, - strand Genetic Position: Chr5, 63.24 cM
• Alliance: Hcar1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A 4 kb IRES-lacZ-neo cassette was inserted in the trans-membrane domain 2 coding region via homologous recombination. (J:314286)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcar1 Mutation: 18 strains or lines available

References

• Original: J:345898 Madaan A, et al., Lactate produced during labor modulates uterine inflammation via GPR81 (HCA(1)). Am J Obstet Gynecol. 2017 Jan;216(1):60.e1-60.e17
• All: 3 reference(s)