Rag1^em3Mvw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rag1^em3Mvw
• Name: recombination activating 1; endonuclease-mediated mutation 3, Michael Wiles
• MGI ID: MGI:7612089
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^em3Mvw page

Mutation origin

• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intragenic deletion, Single point mutation
• Mutation details: This Chr 2:101,474,567 C to T point substitution, facilitated by the base editor BE4Max, is a CAG to TAG causing a Q192X premature stop that results in a null allele. (J:332675)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 123 strains or lines available

References

• Original: J:332675 Sargent JK, et al., Genetically diverse mouse platform to xenograft cancer cells. Dis Model Mech. 2022 Sep;15(9)
• All: 1 reference(s)