Hoxb3os^em1Kabo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxb3os^em1Kabo
• Name: homeobox B3 and homeobox B2, opposite strand; endonuclease-mediated mutation 1, Karam Aoudehen
• MGI ID: MGI:7612311
• Gene: Hoxb3os Location: Chr11:96233860-96244220 bp, - strand Genetic Position: Chr11, 59.85 cM
• Alliance: Hoxb3os^em1Kabo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted the promoter region and the first exon of isoform 1. qRT-PCR indicated that isoform 1 expression was downregulated by 90%, whereas isoform 2 expression did not change in kidneys of homozygotes. No effect on the transcription of the HoxB gene cluster was seen. (J:345935)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb3os Mutation: 3 strains or lines available

References

• Original: J:345935 Weisser I, et al., Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease. J Am Soc Nephrol. 2024 Jan 1;35(1):41-55
• All: 1 reference(s)