Tmem87a^em1Glwn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem87a^em1Glwn
• Name: transmembrane protein 87A; endonuclease-mediated mutation 1, Gary R Lewin
• MGI ID: MGI:7614451
• Gene: Tmem87a Location: Chr2:120185793-120234594 bp, - strand Genetic Position: Chr2, 60.31 cM
• Alliance: Tmem87a^em1Glwn page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination using guide RNAs created an approximately 12.8 kb deletion spanning exons 8 to 15. Single-molecule fluorescent in situ hybridization confirmed the absence of expression in homozygous mice. (J:345910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem87a Mutation: 56 strains or lines available

References

• Original: J:345910 Chakrabarti S, et al., Touch sensation requires the mechanically gated ion channel ELKIN1. Science. 2024 Mar;383(6686):992-998
• All: 1 reference(s)