Trim24^em2Schen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim24^em2Schen
• Name: tripartite motif-containing 24; endonuclease-mediated mutation 2, Shuai Chen
• MGI ID: MGI:7614464
• Synonyms: TRIM24^S1043A
• Gene: Trim24 Location: Chr6:37847746-37943231 bp, + strand Genetic Position: Chr6, 17.07 cM, cytoband B1
• Alliance: Trim24^em2Schen page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Cysteine codon 1043 (AGC) in exon 19 was changed to alanine (GCT) (p.S1043A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation replaces a phosphorylatable residue in the encoded peptide with a phosphoblocker. (J:345293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim24 Mutation: 99 strains or lines available

References

• Original: J:345293 Wei W, et al., TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun. 2022 Jul 8;13(1):3972
• All: 1 reference(s)