Rnf126^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Rnf126^tm1.1Bcgen
• Name: ring finger protein 126; targeted mutation 1.1, Biocytogen
• MGI ID: MGI:7614508
• Gene: Rnf126 Location: Chr10:79594349-79602786 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Rnf126^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344817
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 8. Exons 2-8 and the neomycin selection cassette were removed via cre-mediated recombination in the germline. qRT-PCR confirmed the absence of mRNA expression in various tissues. (J:344817)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf126 Mutation: 29 strains or lines available

References

• Original: J:344817 Liu W, et al., RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy. Adv Sci (Weinh). 2023 Feb;10(5):e2203884
• All: 1 reference(s)