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Klk5em1Mer
Endonuclease-mediated Allele Detail
Summary
Symbol: Klk5em1Mer
Name: kallikrein related-peptidase 5; endonuclease-mediated mutation 1, Marc E Rothenberg
MGI ID: MGI:7614802
Gene: Klk5  Location: Chr7:43491395-43500605 bp, + strand  Genetic Position: Chr7, 28.3 cM
Alliance: Klk5em1Mer page
Mutation
origin
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology generated a 37 bp deletion (CCCTGGAAATGGGCAATGGCTACCCTGATCACAACCC) in exon 1. qRT-PCR confirmed undetectable mRNA expression in the esophagus. (J:344772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klk5 Mutation:  23 strains or lines available
References
Original:  J:344772 Azouz NP, et al., Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Sci Transl Med. 2020 May 27;12(545):eaaz7773
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory