Or51e1^tm1Jplu
Targeted Allele Detail

Summary

• Symbol: Or51e1^tm1Jplu
• Name: olfactory receptor family 51 subfamily E member 1; targeted mutation 1, Jennifer L Pluznick
• MGI ID: MGI:7616972
• Gene: Or51e1 Location: Chr7:102351530-102361261 bp, + strand Genetic Position: Chr7, 54.81 cM
• Alliance: Or51e1^tm1Jplu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:346436
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Null/knockout)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: Flexible Accelerated STOP Tetracycline Operator (tetO)-knockin (FAST) was used to insert a construct containing a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO) and loxP site upstream of the translation initiation site. (J:346436)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Or51e1 Mutation: 21 strains or lines available

Notes

The construct was electroporated into C57BL/6NTac-derived iTL IN2 embryonic stem (ES) cells.

References

• Original: J:346436 Xu J, et al., An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure. Sci Adv. 2024 Mar 22;10(12):eadk1487
• All: 1 reference(s)