Ms4a6d^em2Ywch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ms4a6d^em2Ywch
• Name: membrane-spanning 4-domains, subfamily A, member 6D; endonuclease-mediated mutation 2, Yongwen Chen
• MGI ID: MGI:7618318
• Synonyms: Ms4a6d^Y241G
• Gene: Ms4a6d Location: Chr19:11563970-11582150 bp, - strand Genetic Position: Chr19, 8.45 cM, cytoband B
• Alliance: Ms4a6d^em2Ywch page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• CRISPR/Cas9 technology generated a tyrosine to glycine substitution at amino acid 241 (Y241G). (J:342776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a6d Mutation: 30 strains or lines available

References

• Original: J:342776 Chen Y, et al., Tetraspan MS4A6D is a coreceptor of MHC class II antigen (MHC-II) that promotes macrophages-derived inflammation. Mol Immunol. 2023 Aug;160:121-132
• All: 2 reference(s)