Nudc^{tm1c(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Nudc^{tm1c(KOMP)Mbp}
• Name: nudC nuclear distribution protein; targeted mutation 1c, Mouse Biology Program, UC Davis
• MGI ID: MGI:7618456
• Synonyms: NudC^fl
• Gene: Nudc Location: Chr4:133259853-133273307 bp, - strand Genetic Position: Chr4, 66.25 cM, cytoband D3
• Alliance: Nudc^{tm1c(KOMP)Mbp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:346299
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 133260405 of Chromosome 4 upstream of the critical exons 3 to 7 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 3-7 at position 133263632. The critical exons 3 to 7 are thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene creating a conditional ready exon 3-7 floxed allele. Information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:346299)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nudc Mutation: 21 strains or lines available

References

• Original: J:346299 Garner MA, et al., NUDC is critical for rod photoreceptor function, maintenance, and survival. FASEB J. 2024 Mar 15;38(5):e23518
• All: 1 reference(s)