Supt16^em1Hguo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Supt16^em1Hguo
• Name: SPT16, facilitates chromatin remodeling subunit; endonuclease-mediated mutation 1, Hong Guo
• MGI ID: MGI:7620382
• Gene: Supt16 Location: Chr14:52397876-52434696 bp, - strand Genetic Position: Chr14, 26.83 cM
• Alliance: Supt16^em1Hguo page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 2 to 8. (J:344671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supt16 Mutation: 76 strains or lines available

References

• Original: J:344671 Wang J, et al., Supt16 haploinsufficiency causes neurodevelopment disorder by disrupting MAPK pathway in neural stem cells. Hum Mol Genet. 2023 Feb 19;32(5):860-872
• All: 1 reference(s)