Usp15^em1Peih
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp15^em1Peih
• Name: ubiquitin specific peptidase 15; endonuclease-mediated mutation 1, Huadong Pei
• MGI ID: MGI:7621223
• Gene: Usp15 Location: Chr10:122940911-123032900 bp, - strand Genetic Position: Chr10, 72.31 cM, cytoband D3
• Alliance: Usp15^em1Peih page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRIPSR-cas9 mediated recombination using guide RNAs created a frame shift by excluding exon 2. (J:276458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp15 Mutation: 60 strains or lines available

References

• Original: J:276458 Peng Y, et al., The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019 Mar 15;10(1):1224
• All: 3 reference(s)