Cpsf6^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cpsf6^em1Bcgen
• Name: cleavage and polyadenylation specific factor 6; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7621294
• Gene: Cpsf6 Location: Chr10:117180572-117212903 bp, - strand Genetic Position: Chr10, 65.41 cM
• Alliance: Cpsf6^em1Bcgen page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exon 3. (J:346988)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpsf6 Mutation: 29 strains or lines available

References

• Original: J:346988 Ge Y, et al., Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses. PLoS Pathog. 2024 Feb;20(2):e1012061
• All: 1 reference(s)