Chrna2^tm1.1Slot
Targeted Allele Detail

Summary

• Symbol: Chrna2^tm1.1Slot
• Name: cholinergic receptor nicotinic alpha 2 subunit; targeted mutation 1.1, Shahrdad Lotfipour
• MGI ID: MGI:7621414
• Synonyms: Chrna2^L9'S
• Gene: Chrna2 Location: Chr14:66372488-66390397 bp, + strand Genetic Position: Chr14, 34.36 cM
• Alliance: Chrna2^tm1.1Slot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272596
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Leucine codon 282 (CTC) in exon 5 was changed to serine (AGC) (p.L282S) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 4. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation, at Leu 9' in the transmembrane region 2 (TM2) of the encoded peptide, modifies the physiological response of the receptor to nicotine and acetylcholine. (J:272596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna2 Mutation: 33 strains or lines available

References

• Original: J:272596 Lotfipour S, et al., alpha2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice. Learn Mem. 2017 Jun;24(6):231-244
• All: 2 reference(s)