Fars2^em1Chenk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fars2^em1Chenk
• Name: phenylalanine-tRNA synthetase 2, mitochondrial; endonuclease-mediated mutation 1, Kun Chen
• MGI ID: MGI:7621486
• Gene: Fars2 Location: Chr13:36301373-36721569 bp, + strand Genetic Position: Chr13, 14.44 cM, cytoband A5
• Alliance: Fars2^em1Chenk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs introduced a G to T mutation at position 424 (p.D142Y). This mutation disrupts the aminoacylation activity of the enzyme. (J:339244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fars2 Mutation: 44 strains or lines available

References

• Original: J:339244 Chen X, et al., Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function. Cell Biosci. 2022 Jul 6;12(1):103
• All: 1 reference(s)