Fars2^em3Chenk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fars2^em3Chenk
• Name: phenylalanine-tRNA synthetase 2, mitochondrial; endonuclease-mediated mutation 3, Kun Chen
• MGI ID: MGI:7621488
• Synonyms: Fars2^fl
• Gene: Fars2 Location: Chr13:36301373-36721569 bp, + strand Genetic Position: Chr13, 14.44 cM, cytoband A5
• Alliance: Fars2^em3Chenk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/cas9 mediated recombination using guide RNAs inserted loxP sites around exon 3. (J:339244)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fars2 Mutation: 44 strains or lines available

References

• Original: J:339244 Chen X, et al., Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function. Cell Biosci. 2022 Jul 6;12(1):103
• All: 1 reference(s)