Ccdc183^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc183^em1Osb
• Name: coiled-coil domain containing 183; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7621683
• Synonyms: Ccdc183 KO
• Gene: Ccdc183 Location: Chr2:25498647-25507690 bp, - strand Genetic Position: Chr2, 17.54 cM, cytoband A3
• Alliance: Ccdc183^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an 8,819-bp deletion including the entire coding region of the gene. Western blot analysis demonstrated the absence of protein expression in the testis and cauda epididymal spermatozoa of homozygous mutant mice. (J:342837)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccdc183 Mutation: 25 strains or lines available

References

• Original: J:342837 Shimada K, et al., CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility. Development. 2023 Nov 1;150(21)
• All: 1 reference(s)