Ppp1r12b^em1Chana
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppp1r12b^em1Chana
• Name: protein phosphatase 1, regulatory subunit 12B; endonuclease-mediated mutation 1, Audrey N Chang
• MGI ID: MGI:7621836
• Synonyms: PPP1R12B^f
• Gene: Ppp1r12b Location: Chr1:134682396-134883680 bp, - strand Genetic Position: Chr1, 58.24 cM, cytoband F
• Alliance: Ppp1r12b^em1Chana page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/cas9 mediated recombination using guide RNAs inserted loxP sites flanking exon 1. (J:346986)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r12b Mutation: 75 strains or lines available

References

• Original: J:346986 Lee E, et al., The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo. J Biol Chem. 2024 Jan 13;300(2):105652
• All: 1 reference(s)