Sipa1l1^tm1Taki
Targeted Allele Detail

Summary

• Symbol: Sipa1l1^tm1Taki
• Name: signal-induced proliferation-associated 1 like 1; targeted mutation 1, Tetsu Akiyama
• MGI ID: MGI:7621907
• Synonyms: Sipa1l1^-
• Gene: Sipa1l1 Location: Chr12:82216138-82498560 bp, + strand Genetic Position: Chr12, 38.14 cM
• Alliance: Sipa1l1^tm1Taki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345320
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A nuclear localization signal-LacZ-poly A cassette, followed by a PGK-neo-poly A cassette was inserted at the first methionine site via homologous recombination in ES cells. Western blot analysis confirmed the absence of protein expression in whole brain as well as region-specific lysates (including brainstem, cerebellum, cerebral cortex, and hippocampus) from adult homozygous mutant mice. (J:345320)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sipa1l1 Mutation: 82 strains or lines available

References

• Original: J:345320 Matsuura K, et al., SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling. J Neurosci. 2022 Mar 23;42(12):2448-2473
• All: 1 reference(s)