Clec10a^m1
Spontaneous Allele Detail

Summary

• Symbol: Clec10a^m1
• Name: C-type lectin domain family 10, member A; mutation 1
• MGI ID: MGI:7624304
• Synonyms: Clec10a^c.706C>T, Clec10a^c.706T
• Gene: Clec10a Location: Chr11:70057449-70061662 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Clec10a^m1 page

Mutation origin

• Strain of Origin: NC/Nga

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The NC/Nga strain has a spontaneous NM_010796:c.706C>T:p.Q236* mutation in exon 9. The mutation, in the C-type lectin-like domain (CTLD) of the encoded peptide, results in a truncated C-terminus and prevents cell surface expression of the protein. (J:283174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec10a Mutation: 23 strains or lines available

References

• Original: J:283174 Kanemaru K, et al., Clec10a regulates mite-induced dermatitis. Sci Immunol. 2019 Dec 6;4(42)
• All: 1 reference(s)