Gm41261^em1Geh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gm41261^em1Geh
• Name: predicted gene, 41261; endonuclease-mediated mutation 1, Gregg E Homanics
• MGI ID: MGI:7624349
• Gene: Gm41261 Location: Chr15:6890929-6902168 bp, + strand Genetic Position: Chr15, Syntenic
• Alliance: Gm41261^em1Geh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 306 bp deletion in exon 1. RT-PCR confirmed the expression of a 306 bp smaller lncRNA in the cortex. Gm41261 is a natural antisense transcript to Osmr intron 1, however abundance of Osmr in the cortex is unaltered. (J:345829)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gm41261 Mutation: 0 strains or lines available

References

• Original: J:345829 Plasil SL, et al., Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice. Genes Brain Behav. 2024 Feb;23(1):e12886
• All: 1 reference(s)