Pycr1^em1Zhob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pycr1^em1Zhob
• Name: pyrroline-5-carboxylate reductase 1; endonuclease-mediated mutation 1, Binquan Zhou
• MGI ID: MGI:7624490
• Gene: Pycr1 Location: Chr11:120527591-120534602 bp, - strand Genetic Position: Chr11, 84.37 cM
• Alliance: Pycr1^em1Zhob page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exons 3-6 created a deletion spanning from exon 3 to 6. (J:345302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycr1 Mutation: 21 strains or lines available

References

• Original: J:345302 Xue Z, et al., Metabolomic and transcriptomic studies of improvements in myocardial infarction due to Pycr1 deletion. J Cell Mol Med. 2023 Jan;27(1):89-100
• All: 1 reference(s)