Chapir^em1Kwan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chapir^em1Kwan
• Name: cardiac-hypertrophy-associated piRNA; endonuclease-mediated mutation 1, Kun Wang
• MGI ID: MGI:7627348
• Gene: Chapir Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Chapir^em1Kwan page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/cas9 mediated recombination created a null allele. PCR and qRT-PCR analysis confirmed the splicing and expression of Gm12648 were not altered. Northern blot analysis confirmed the loss of expression in homozygous mice. (J:310115)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chapir Mutation: 0 strains or lines available

References

• Original: J:310115 Gao XQ, et al., The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA. Nat Cell Biol. 2020 Nov;22(11):1319-1331
• All: 1 reference(s)