Ighg2c^em1Wliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ighg2c^em1Wliu
• Name: immunoglobulin heavy constant gamma 2C; endonuclease-mediated mutation 1, Wanli Liu
• MGI ID: MGI:7627370
• Synonyms: mIgG2c-G400R
• Gene: Ighg2c Location: Chr12:113251009-113252552 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg2c^em1Wliu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a GGG to AGG change resulting in a glycine to arginine substitution at position 400 (p.G400R). The mouse G400R mutation corresponds to the human G396R protective Asia-specific variant for progression and survival of colorectal cancer patients. (J:322180)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg2c Mutation: 16 strains or lines available

References

• Original: J:322180 Yang B, et al., An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022 Mar 15;132(6):e153454
• All: 1 reference(s)